Pyogenic Granuloma-like Amelanotic Melanoma of the Fingernail

Amelanotic melanoma is an atypical that presents without pigmentation and can thus be misdiagnosed as benign neoplasm. Ungual trauma induce amelanotic of the fingernail well pyogenic granuloma (PG). We present case a patient in his 60s with PG-like lesion on third nail plate was preceded by ungual one year ago. A shave biopsy revealed ulcerated nodule composed epitheloid cells melanocytic atypia, extending 1.7 mm. Features were consistent melanoma, confirmed SOX10, S100, MART-1, HMB45 immunostaining. This demonstrates integral role histopathology immunostaining differentiating PG from thereby, preventing metastasis. this to improve clinicians’ ability recognize melanomas emphasize importance such cases ensure timely treatment outcomes.